Studies and Publications on micromechanical tissue repair

 

Here is a list of studies and publications on micromechanical tissue repair.
The most recent compendium on micromechanical tissue repair is:

Rubin, C.; Bolander, M.; Ryaby, J.P.; Hadjiargyrou, M.: The use of low-intensity ultrasound to accelerate the healing of fractures.
JBJS, The Journal of Bone & Joint Surgery, VOL.83-A, No.2, 259 – 270, 2001

Further studies are:

  •  
 Studies summarizing the efficiency of low-intensity plused ultrasound to accelerate fresh fracture healing
Rubin, C.; Bolander, M.; Ryaby, J.P.; Hadjiargyrou, M.: The use of low-intensity ultrasound to accelerate the healing of fractures. JBJS, The Journal of Bone & Joint Surgery, VOL.83-A, No. 2, 259 – 270, 2001

Warden, S.J.; Bennell, K.L.; McMeeken, J.M.; Wark, J.D.: Acceleration of fresh fracture repair using the sonic accelerated fracture healing system (SAFHS): A review. Calcif Tissue Int. 66:157 – 163, 2000

Hadjiargyrou, M.; McLeod, K.; Ryaby, J.P.; Rubin, C.: Enhancement of fracture healing by low intensity ultrasound. Clinical Orthopaedics and Related Research No. 355S, Oct, 1998

Frankel, V.H.; Results of prescription use of pulse ultrasound therapy in fracture management. In: Szabó, Z.; Lewis, J.E.; Fantini, G.A.; Savalgi, R.S. (eds) Surgical Technology International VII. Universal Medical Press; San Francisco, pp 389-393, 1998

Orthner, E.: Frakturheilung und Ultraschall. Jatros Orthopädie 4/98

Lane, J.M., M.D. et. al.: Ultraschallbehandlungen bei 2.126 Frakturen. Jatros Orthopädie 4/98

Duarte, L.R.: The stimulation of bone growth by ultrasound. Arch. Ortho. Trauma Surg. 101 : 153-159 (1983)

 
  •  
 Studies reporting on the efficiency of low-intensity pulsed ultrasound in cases of human fractures/osteotomies
Sato, W.; Matsushita, T; Nakamura, K.:  Acceleration of increase in bone mineral content by low-intensity ultrasound energy in leg lengthening. Ultrasound Med. 18:699–702, 1999

Kristiansen, T.K.; Ryaby, J.P.; McCabe, J.; Frey, J.J.; Roe, L.R.: Accelerated healing of distal radial fractures with the use of specific, low-intensity ultrasound. A multicenter, prospective, randomized, double-blind, placebo-controlled study.
J. Journal Bone Joint Surg. Am. 79-961-73, 1997

Cook, S.D.; Ryaby, J.P.; McCabe, J.; Frey, J.J.; Heckman, J.D.; Kristiansen, T.K.: Acceleration of tibia and distal radius fracture healing in patients who smoke. Clinical Orthopaedics, 337:19 –207, 1997

Tanzer, M.; Harvey, E.; Kay, A.; Morton, P.; Bobyn, J.D.: Effect of noninvasive low intensity ultrasound on bone growth into porous-coated implants.  J. Orthop. Res. 14:901-906, 1996

Heckman, J.D.;  Ryaby, J.P.; McCabe, J.; Frey, J.J.; Kilcoyne, R.F.: Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound. Journal of Bone and Joint Surgery, Vol. 76-A, No. 1, pp.: 26-34 (1994)

 
  •  
 Studies reporting on the efficiency of low-intensity pulsed ultrasound in cases of animal model fractures/osteotomies

Mayr, E.; Laule, A.; Suger, G.; Claes, L.; Rüter, A.:  Regenerate maturation aided by low intensity ultrasound in callus distraction. Freund Publishing House Ltd., 1999

Inui, K.: Die Wirkung von nicht-invasivem, niederenergetischem Ultraschall auf die Distraktionsosteogenese im Tiermodell. Jatros Orthopädie 4/98

Sparado, J.A.; Albanese, S.A.: Application of low-intenity ultrasound to growing bone in rats. Ultrasound Med. Biol. 24:567-573, 1998

Ito, M.; Azuma, Y.; Harady, Y.; Takagi, H.; Ohta, T.; Komoriya, K.; Jingushi, S.: Low intensity pulsed ultrasound accelerates fracture healing in a rat femoral fracture model. Trans. Orthop. Res. Soc. 23:732, 1996

Wang, S.J.; Lewallen, D.G.; Bolander, M.E.; Chao, E.Y.S.; Ilstrup, D.M.; Greenleaf, J.F.: Low-Intensity Ultrasound Treatment Increases Strength in a Rat Femoral Fracture Model. J. of Orthopaedic Research 12 : 40-47 (1994)

Pilla, A.A.; Mont, M.A.; Nasser, P.R.; Khan, S.A.; Figuiredo, M.; Kaufman, J.J.; Siffert, R.S.: Non-invasive low-intensity pulsed ultrasound accelerates bone healing in the rabbit. Journal of Orthopaedic Trauma, 4:246-253, 1990

Klug, W; Franke, W.G.; Schulze, M.: Tierexperimentelle szintigraphische Verlaufsbeobachtungen der sekundären Knochenbruchheilung ohne und mit Ultraschallstimulation. Z.Exp.Chir.Transplant. Künstliche Organe, 19(3):185-195,
1986

Reuter, U.; Strempel, F.; Knoch, H.G.: Beeinflussung der Knochenbruchheilung durch Ultraschall im Tiermodell. Z. Exp. Chir. Transplant. Künstliche Organe, 17(5):290-297, 1984

Duarte, L.R.: The stimulation of bone growth by ultrasound. Arch. Orthop. And Trauma Surg., 101:153-159, 1983

Dyson, M. and Brookes, M.: Stimulation of bone repair by ultrasound.
Ultrasound Med. Biol. 8:61-66 (1982)

 
  •  
 In-vitro studies reporting on the efficiency of low-intensity pulsed ultrasound
Doan, N; Reher, P.; Meghji, S.; Harris, M.: In vitro effects of therapeutic ultrasound on cell proliferation, protein synthesis, and cytokine production by human fibroblasts, osteoblasts, and monocytes. J. Oral Maxillofac Surg.
57:409-419, 1999

Nolte, P.A.; Klein-Nulend, J.; Albers, G.H.R.; Marti, R.K.; Swemeins, C.M.;
Goei, S.W.; Burger, E.H.: Low intensity ultrasound stimulates in vitro endochondral ossification. Calcif Tissue Int. 64 (suppl. 1):S62, 1999

Kokubu, T.; Matsui, N.; Fujioka, H.; Tsunoda, M.; Mizunoi, K.: Low intensity pulsed ultrasound exposure increases prostaglandin E2 production via the induction of cyclooxygerase-2 mRNA in mouse osteoblasts. Biochem. Biophys. Res. Commun. 256:284-287, 1999

Hadjiargyrou, M.; McLeod, K.J.; Halsey, M.; Rubin, C.T.: The temporal expression of osteopontin mRNA in the fracture callus is altered by low intensity ultrasound. J. Bone Miner Res. 12(suppl.1):S425, 1997

Yang, K.H.; Parvizi, J.; Wang, S.J.; Lewallen, D.G.; Kinnick, R.R.; Greenleaf, J.F.; Bolander, M.E.: Exposure to low-intensity ultrasound increases aggrecan gene expression in a rat femur fracture model. Journal of Orthopaedic Research, 14(5):802-809, 1996

Ryaby, J.T.; Mathew, J.; Pilla, A.A.; Duarte-Alves, P.: Low-intensity pulsed ultrasound modulates adenylate cyclase activity and transforming growth factor beta synthesis. Electromagnetics in Biology and Medicine, ed. By C.T. Brighton and S.R. Pollock, San Francisvo Press, 95-100, 1991

Ryaby, J.T.; Duarte-Alves, P.; Pilla, A.A.: Ultrasound and static mechanical force affect second messenger activity in bone cell cultures. Trans. Orthop. Res.Soc. 15:131, 1990

Ryaby, J.T.; Bachner, E.J.; Bendo, J.A.; Dalton, P.F.; Tannenbaul, S.; Pilla, A.A.: Low intensity pulsed ultrasound increases calcium incorporation in both differentiating cartilage and bone cell cultures. Orthopaedic Research Society, 131, New Orleans, L.A.

Binderman, J.; Zor, U.; Kaye, A.M.; Shimshoni, Z.; Harrell, A. and Somjen, D.: The Transduction of mechanical force into biochemical events in bone cells may involve activation of phospholipase A2. Calcif. Tiss. Intl. 42 : 261 (1988)

Buckley, M.J.; Banes, A.J.; Levin, L.G.; Sumpio, B.E.; Sato, M.; Jordan, R.;
Gilbert, T.; Link, G.W. and Transon Tay, R.: Osteoblasts increase their rate of division and align in response to cyclic, mechanical tension in vitro. Bone and Mineral 4 : 225 (1988)

Bolander, E.M.: Aggrecansynthese bei Frakturkallus mittels Ultraschall verstärkt. Jatros Orthopädie 4/98

 
  •  
 Studies on the mechanism of low-intensity pulsed ultrasound
Reher, P.; Doan, N.; Bradnock, B.; Meghji, S.; Harris, M.: Effect of ultrasound on the production of IL-8, basic FGF and VEGF. Cytokine 11:416-423, 1999

Parvizi, J.; Parpura, V.; Kinnick, R.R.; Greenleaf, J.F.: Low intensity ultrasound increases intracellular concentration of calcium in chondrocytes. Trans. Orthop. Res. Soc. 22:465, 1997

Wu, C.C.; Lewallen, D.G.; Bolander, M.E.; Bronk, J.; Kinnick, R.; Greenleaf, J.F.: Exposure to low intensity ultrasound stimulates aggrecan gene expression by cultured chondrocytes. Trans. Orthop. Soc. 21:622, 1996

Ryaby, J-T.; Mathew, J.; Duarte-Alves, P.: Low intensity pulsed ultrasound affects adenylate cyclase and TGF-b. synthesis in osteoblastic cells. Trans. Orthop. Res. Soc. 17:590, 1992

Pilla, A.A.; Mont, M.A.; Nasser, P.; Kahn, S.A.; Figneiredo, M.; Kaufman, J.J.; Siffert, R.S.: Non Invasive Low-Intensity Pulsed Ultrasound Accelerated Bone Healing in the Rabbit. Journal of Orthop. Trauma, Vol. No. 4, No. 3, 246-253, 1990

Reuter, I.; Strempel, F.; John, F. und Knoch, H.-G.: Beeinflussung der Knochenbruchheilung durch Ultraschall im Tiermodell. Z. exp. Chir. Transplant. Künstl. Organe 17, H.5., 290-297 (1984)

 
  •  
 Others
Wolff, J.: Das Gesetz der Transformation der Knochen. Verlag August Hirschwald, Berlin, 1992